Thank you for making this resource available. I have been using it as a reference in my modeling work (mostly single compartmental at present, but it’s still been very useful).
I had a quick question about the synaptic time constants that are reported in the NMC portal. They seem to be much longer than I would expect. For example, I would expect a typical GABA A synapse to have a rise time of ~0.5 ms and a decay time of ~8 ms (references below). (Time constants on this scale are important for the production of PING gamma.) However, many of the time constants from basket cells are reported to be much longer. For example, the L23_LBC to L23_PC rise and decay times are 5.5 and 48 msec, respectively. NBC and SBC have similar time constants.
Is this due to the synaptic response being a mix of GABA A and GABA B ? Is there any way to separate out the individual contributions?
Postdoctoral Researcher, Boston University
Wang, X. J., & Buzsáki, G. (1996). Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 16(20), 6402–6413. https://doi.org/citeulike-article-id:134404
(GABA A decay of ~10 ms)
Kramer, M. a., Roopun, A. K., Carracedo, L. M., Traub, R. D., Whittington, M. a., & Kopell, N. J. (2008). Rhythm generation through period concatenation in rat somatosensory cortex. PLoS Computational Biology, 4(9). https://doi.org/10.1371/journal.pcbi.1000169
(GABA A decay of ~5 ms for basket cells)